Pre-clinical laboratory evaluation of the new ‘AF’ arterial line filter range:

作者: Gemma Yarham , John Mulholland

DOI: 10.1177/0267659110377679

关键词:

摘要: Introduction: The presence of emboli was recognised relatively early in the history open heart surgery. produced during cardiopulmonary bypass have predisposition to distribute into, and ultimately obstruct, microvessels all tissues. Sorin Group has recently developed a new range arterial line filters. Before AF filters released for pre-launch clinical trials, our group performed vitro laboratory testing against selection commercially available on global market.Results: AF620 AF640 demonstrate both smallest prime volume surface contact area (92ml 290cm2, respectively).The results GME Handling Efficiency experiments ranged by 39.6%, from 95.9% 56.3%. In terms an air bolus handling, Limit Bolus experiment 97ml, 147.5ml down 50ml. pressure drop across measured under steady state experimental conditions. All a...

参考文章(15)
R. Guidoin, Y. Laperche, L. Martin, J. Awad, J. Winchester, Disposable filters for microaggregate removal from extracorporeal circulation. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 71, pp. 502- 516 ,(1976) , 10.1016/S0022-5223(19)40167-0
Gianfranco B. Fiore, Umberto Morbiducci, Raffaele Ponzini, Alberto Redaelli, Bubble Tracking Through Computational Fluid Dynamics in Arterial Line Filters for Cardiopulmonary Bypass ASAIO Journal. ,vol. 55, pp. 438- 444 ,(2009) , 10.1097/MAT.0B013E3181B3800C
Michael A. Borger, Charles M. Peniston, Richard D. Weisel, Marie Vasiliou, Robin E.A. Green, Christopher M. Feindel, Neuropsychologic impairment after coronary bypass surgery: effect of gaseous microemboli during perfusionist interventions. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 121, pp. 743- 749 ,(2001) , 10.1067/MTC.2001.112526
JE Lynch, JB Riley, Microemboli detection on extracorporeal bypass circuitsa Perfusion. ,vol. 23, pp. 23- 32 ,(2008) , 10.1177/0267659108094350
Andrew J. Baker, Basem Naser, Mark Benaroia, C. David Mazer, Cerebral microemboli during coronary artery bypass using different cardioplegia techniques The Annals of Thoracic Surgery. ,vol. 59, pp. 1187- 1191 ,(1995) , 10.1016/0003-4975(95)00128-8
M. Schönburg, P. Urbanek, G. Erhardt, B. Kraus, U. Taborski, A. Mühling, S. Hein, M. Roth, HJ Tiedtke, WP Klövekorn, Significant reduction of air microbubbles with the dynamic bubble trap during cardiopulmonary bypass. Perfusion. ,vol. 16, pp. 19- 25 ,(2001) , 10.1177/026765910101600104
Eduardo A. Tovar, Carlos Del Campo, Alan Borsari, Robin P. Webb, Jeffrey R. Dell, Paul B. Weinstein, Postoperative management of cerebral air embolism: gas physiology for surgeons The Annals of Thoracic Surgery. ,vol. 60, pp. 1138- 1142 ,(1995) , 10.1016/0003-4975(95)00531-O
Michal Barak, Yeshayahu Katz, Microbubbles : Pathophysiology and clinical implications Chest. ,vol. 128, pp. 2918- 2932 ,(2005) , 10.1378/CHEST.128.4.2918
Timothy W Willcox, Simon J Mitchell, Des F Gorman, Venous air in the bypass circuit: a source of arterial line emboli exacerbated by vacuum-assisted drainage The Annals of Thoracic Surgery. ,vol. 68, pp. 1285- 1289 ,(1999) , 10.1016/S0003-4975(99)00721-3