Chloroquine reduces the number of asialo-glycoprotein receptors in the hepatocyte plasma membrane.
作者： H. Tolleshaug , T. Berg
DOI: 10.1016/0006-2952(79)90586-0
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摘要: Abstract Rat hepatocytes which had been incubated with chloroquine in concentrations ranging from 0.2 to 1.0 mM showed markedly reduced ability take up asialo-glycoproteins. Chloroquine no effect on the actual binding of asialo-orosomucoid receptor hepatocytes. caused a progressive reduction capacity plasma membrane for asialo-glycoproteins; that exposed 30 min at 37°C, was 15 per cent controls. The results support idea asialo-glycoprotein receptors are internalized regardless ligand.
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