Efficacy of influenza vaccination in HIV-positive patients: a systematic review and meta-analysis

摘要: Background International treatment guidelines recommend that HIV-positive patients be vaccinated for influenza annually. Evidence supporting this recommendation is limited. We assessed the efficacy of vaccines in preventing through a systematic review and meta-analysis. Methods We searched 10 electronic databases independently, duplicate (from inception to June 2007). extracted data on study design, population characteristics outcomes related symptoms antibody titres. pooled using random effects model conducted sensitivity analyses evaluate heterogeneity. Results We included four studies. Three studies were evaluable meta-analysis yielded relative risk reduction (RRR) 66% [95% confidence interval (CI) 36–82%; I2=73%]. One case–control an odds ratio 1.98 (95% CI 0.75–5.20). When we heterogeneity according found highest quality, randomized clinical trial (RCT), most conservative estimate (RRR 41%; 95% 2–64%). Interpretation Evidence vaccination individuals limited, poorly quantified characterized by substantial methodological shortcomings. A reasonable effectiveness cannot derived from these data. There urgent need trials guide policy practice.