Evidence that appearance of thymulin in plasma follows lymphoid chimerism and precedes development of immunity in patients with lethal combined immunodeficiency transplanted with T cell-depleted haploidentical marrow.

摘要: Thymulin, a peptide secreted by human thymic epithelial cells, circulates in peripheral blood. Levels of plasma thymulin (FTS-Zn) activity were analyzed 21 patients with lethal combined immunodeficiency disorders who treated transplantation HLA-haplotype-mismatched parental bone marrow depleted T cells differential agglutination soybean agglutinin and E-rosetting (SBA-E-BMT). Among these infants, 15 severe (SCID) 6 had (CID) Omenn's syndrome or CID cell predominance (CIDTP). In contrast to normal infants possess high levels activity, 20 the demonstrated undetectable low for their age at admission prior transplantation. Following SBA-E-BMT, however, became detectable 17 18 evaluable reached near-normal between 125 days posttransplant. whom timing engraftment could be established emergence donor lymphocytes, appeared approximately same time as lymphoid chimerism was detected, all engrafted immunologically reconstituted, increment preceded development immune functions. These studies support concept that marrow-derived graft can provide stimulus necessary induction secretory function dysplasia. Further, immunologic reconstitution not seen following SBA-E-BMT unless until recovery thymus been observed.