The locomotion of fibroblasts in culture: III. Movements of particles on the dorsal surface of the leading lamella

摘要: Abstract A fibroblast, when moving on a plane substratum and colliding with small particle adherent to the substratum, commonly picks up transports it backwards. Such particles while back are attached dorsal surface of cell, i.e. side exposed medium. On average, in about 8 min they travel 14 μm reference front edge cell 10 showing little fluctuation speed or direction. They then go into random oscillation move sideways. The backward is approximately equal that ruffles similar situation, but significantly slower than large pinocytotic vacuoles. It proposed lamellipodia at end result from outbursts assembly new there, producing folding, excess steadily flowing backwards where unimpeded by adhesions carrying it.