Therapeutic vaccines: challenges of chronic viral infections

摘要: Therapeutic vaccination is still a controversial subject regarding its potentially beneficial effects. It often forgotten that therapeutic has been used for at least 40 years in modern medicine. Doctors treated allergies by administering the allergen different route and form than when it causes allergic reaction. The aim here was to modulate direction of host immune response from ‘proallergic’ histamine releasing T-helper 2-like an ‘antiallergic’ γIFN-producing 1-like response. Thus, use vaccine deliver antigen way This exactly with chronic viral infection. A infection has, depending on virus, most probably modulated become less effective against invading thereby promoting persistence. Different viruses strategies do this, consequently, should be designed remedy, correct, or partially more antiviral direction. There are no examples yet human infections where found undisputedly mediate clearance Numerous reports have suggested did prime reactivate responses, which may regarded as including CD4+ cells cytotoxic T lymphocytes. However, substantial hurdles need overcome before we several therapeutically active vaccines, meaning they indeed affect disease progression commonly clinic. These difficulties problems discussed present review.