Parvoviral Probe of DNA Replication in Mammalian Cells Exposed to Genotoxic Agents

摘要: Exposure of mammalian cells to a variety chemical and physical agents depresses the overal rate DNA synthesis [1]. Part this inhibition can be ascribed disturbance initiation cell replication. The cellular genome comprises numerous units which contain each one replication origin are replicated sequentially. Genotoxic agents, in particular direct or indirect inducers breaks, apparently delay normally programmed for time subsequent treatment [2]. Single-strand breaks might lead loss chromosomal segments if not sealed at temporary lowers risk by providing with more repair. lack displayed human derived from Ataxia telangiectasia patients is associated an increased sensitivity lethal effect [3].