Hemoglobin E: a common hemoglobinopathy among children of Southeast Asian origin

摘要: With the recent immigration of Southeast Asians to Canada, hemoglobin E has become a frequent diagnosis. The clinical and hematologic findings in 42 children (mean age 4.3 years) with are presented. There were 33 heterozygotes (having trait), 6 homozygotes EE) 3 double E-beta-thalassemia). had low-normal levels mean corpuscular volumes; coexisting iron deficiency, present 62% these children, resulted substantially lower levels, very low volumes than expected on electrophoresis. EE only slightly anemic, but those E-beta-thalassemia severe anemia required long-term transfusion therapy. Nutritional factors parasitic infestations main causes depletion, which was common, particularly less 2 years old (87%). Physicians patients Asian origin should be aware presentation hemoglobinopathies.