The isoprostanes: unique products of arachidonic acid oxidation-a review.

摘要: The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation arachidonic acid independent cyclooxygenase enzyme. purpose this article is to summarize our knowledge regarding and discuss what avenues for future research. Novel aspects related biochemistry isoprostane formation methods by which these analyzed, including potential pitfalls that may occur during analysis, discussed first. possess potent biological activity, their role mediating certain detrimental effects oxidant stress then examined. A considerable portion review deals with utility measuring as markers injury both vitro vivo. number studies have shown be extremely accurate lipid animal models oxidative illuminated association human diseases.