Role of Polymer Architecture on the Activity of Polymer–Protein Conjugates for the Treatment of Accelerated Bone Loss Disorders

摘要: Polymers of similar molecular weights and chemical constitution but varying in their macromolecular architectures were conjugated to osteoprotegerin (OPG) determine the effect polymer topology on protein activity vitro vivo. OPG is a that inhibits bone resorption by preventing formation mature osteoclasts from osteoclast precursor cell. Accelerated loss disorders, such as osteoporosis, rheumatoid arthritis, metastatic disease, occur result increased osteoclastogenesis, leading severe weakening bone. has shown promise treatment disorders; however, it rapidly cleared circulation through rapid liver uptake, frequent, high doses are necessary achieve therapeutic benefit. We aimed improve effectiveness creating OPG–polymer bioconjugates, employing reversible addition–fragmentation chain transfer polymerization create well-defined polymers with branching densities f...