ERM proteins: From cellular architecture to cell signaling
作者： Sophie Louvet-Vallée
DOI: 10.1016/S0248-4900(00)01078-9
关键词:
摘要: ERM (ezrin/radixin/moesin) proteins, concentrated in actin rich cell-surface structures, cross-link filaments with the plasma membrane. They are involved formation of microvilli, cell-cell adhesion, maintenance cell shape, motility and membrane trafficking. Recent analyses reveal that they not only cytoskeleton organization but also signaling pathway. play an important role activation members Rho family by recruiting their regulators. The functions proteins regulated conformational charges: intramolecular interaction between N- C-terminal domains charges masks several binding sites, leading to a dormant protein. Different signals regulate modulating these interactions. involvement many pathways has led study during development different species.
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