Treatment of skin swellings with C1-inhibitor concentrate in patients with hereditary angio-oedema.
作者： K. Bork , P. Staubach , J. Hardt
DOI: 10.1111/J.1398-9995.2007.01577.X
关键词:
摘要: Background: Skin swellings are the most frequent symptoms in hereditary angio-oedema (HAE) arising out of C1-inhibitor (C1-INH) deficiency. They may be painful and impact daily activities patients. Detailed clinical data concerning treatment skin by C1-INH concentrate have not been reported yet. Methods: From 1976 through 2007, a total 2104 skin-swelling attacks 47 patients with HAE were treated concentrate. Time to relief duration documented during personal interviews using standardized questionnaires. The results compared 9046 untreated same patients. Results: first sign efficacy was slowdown progress accompanied decreased feeling tension pain swollen area. mean time 1.1 ± 1.4 h 50.4 ± 33 h swellings. Improvement facial took longer than extremities, genitals or trunk. 1.7 day 3.2 day ones. In swellings, there long-lasting control no rebound within 48 h following drug administration laryngeal oedema observed. No severe side-effects occurred. Conclusions: has proven highly effective safe for treating
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