Impact of rivaroxaban plasma concentration on perioperative red blood cell loss

摘要: BACKGROUND This study investigates the impact of preoperative calculated rivaroxaban (RXA) plasma concentration on perioperative red blood cell (RBC) loss. STUDY DESIGN AND METHODS In this retrospective single-center study, we identified patients with RXA intake according to a determination levels within 96 hours before surgery. at beginning surgery was then from last using single-compartment pharmacokinetic model four categories (≤20, 21-50, 51-100, and >100 μg/L). Patients were classified into high (≥500 mL) or low (<500 mL) expected loss. Perioperative bleeding determined by calculating RBC loss. RESULTS We analyzed 308 surgical interventions in 298 during period January 2012 July 2018. Among undergoing loss, loss varied 164 mL (standard deviation [SD], 189) 302 mL (SD, 397) (p = 0.66), and no association observed. In found significant correlation (Pearson's coefficient, 0.29; p 0.002). increased rising 575 mL 365) 20 μg/L less up 1400 mL 1300) concentration greater than 100 μg/L. associated increase 840 mL (95% confidence interval, 360-1300; p < 0.001). Transfusion fresh frozen units tended concentrations greater The proportion treated prothrombin complex concentrate coagulation factor XIII significantly higher concentrations. CONCLUSION Only