The immunology of ankylosing spondylitis and rheumatoid arthritis: a tale of similarities and dissimilarities.

摘要: Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are immune-mediated inflammatory joint diseases with the potential for significant target organ damage. Genetic factors play an important role in defining disease susceptibility. Both mediated part by TNF, since anti-TNF therapies have proved effective both AS RA. Despite their similarities, genetic elements associated respective differ, most notably HLA associations, being class I alleles RA II alleles. has a predilection axial joints whereas targets peripheral joints, but immunological basis of that distinction is unknown. Autoantibody formation hallmark RA, notable “seronegative” disease. Growing knowledge new aspects host immune response (such as innate responses Th17 cells) adding to insights into shared mechanisms pathogenesis between these two diseases.