Reduced metabolic rate during β-adrenergic blockade in humans
作者： Stephen Welle , Ronald G. Schwartz , Marcia Statt
DOI: 10.1016/0026-0495(91)90053-Y
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摘要: We previously reported that 1 week of propranolol treatment (160 to 240 mg/d, orally) reduced resting metabolic rate (RMR) an average 9% in healthy men. To determine whether this response was caused by the 25% reduction serum triidothyronine (T3), rather than beta-adrenergic blockade, we examined effect nadolol on RMR five Nadolol is a nonselective antagonist does not affect T3 production. After 6 10 days (240 mg/d), mean postabsorptive declined 7% (P less .01), with no significant change or thyroxine (T4) concentrations. This significantly different from hospitalized control group received drug and had RMR, (previously published data). slightly thermic meal (12%), but statistically significant. Mean postprandial 8% lower after mainly because meal. These data suggest activity makes small contribution energy expenditure man.
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