High-salt diets during pregnancy increases renal vascular reactivity due to altered soluble guanylyl cyclase-related pathways in rat offspring☆

摘要: Adverse prenatal factors such as overtake of salt or fat food are potential risks for cardiovascular diseases in offspring. This study tested the hypothesis that high-salt (HS) diets may influence renal vascular tone and attenuates signaling pathways related to soluble guanylyl cyclase (sGC) or/and large-conductance Ca(2+)-activated K(+) (BKCa) channels Pregnant rats were fed either normal (NS) (1% NaCl) HS (8% diet whole gestation. Offspring maintained on NS diets. Renal interlobar arteries offspring responses phenylephrine (Phe), signal sGC. Phe induced higher vessel tension Following pretreatment with BKCa channel inhibitor iberiotoxin, Phe-mediated vasoconstrictions decreased compared NS. constrictions following NO synthase N(G)-nitro-l-arginine methyl ester sGC 1H-1,2,4-oxadiazolo-4,3-quinoxalin-1-one less sensitive than The whole-cell currents component not changed smooth muscle cells from arteries, whereas stimulated by activator BAY41-2272 reduced protein expressions β1 β2 reduced. results showed chronic overintake during pregnancy could increase affected included down-regulation function expression.