Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches.
作者： Edwin J. Yoo , Christie A. Ojiaku , Krishna Sunder , Reynold A. Panettieri
关键词:
摘要: Asthma manifests as airway hyperresponsiveness and inflammation, including coughing, wheezing, shortness of breath. Immune cells structural orchestrate asthma pathophysiology, leading to mucus secretion, narrowing, obstruction. Phosphoinositide 3-kinase, a lipid kinase, plays crucial role in many the cellular molecular mechanisms driving pathophysiology represents an attractive therapeutic target. Here, we summarize diverse roles phosphoinositide 3-kinase pathogenesis discuss novel approaches treatment.
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