Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery
作者： Yi Zhang , Ruirui Wang , Jian Wu , Qi Shen
DOI: 10.1016/J.IJPHARM.2012.02.013
关键词:
摘要: The present study aims to develop self-microemulsifying drug delivery systems (SMEDDS) in sustained-release pellets of puerarin enhance the oral bioavailability puerarin. performances puerarin-SMEDDS including oils, emulsifiers, and co-emulsifiers were evaluated. Pseudo-ternary phase diagrams shows that optimized formulation consisted castor oil as phase, Cremophor EL emulsifier, 1,2-propanediol co-emulsifier. SMEDDS prepared via extrusion-spheronization. particle size distributions formulations determined using transmission electron microscopy scanning electronic microscopy. mean was 50 ± 8 nm. pharmacokinetics tablets evaluated compared beagle dogs. absolute enhanced by approximately 2.6-fold with tablet. relative (F(rel)) 259.7% tablet group. results demonstrated had a effect, could remarkably improve
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