The endocannabinoid system and associative learning and memory in zebrafish

摘要: In zebrafish the medial pallium of dorsal telencephalon represents an amygdala homolog structure, which is crucially involved in emotional associative learning and memory. Similar to mammalian amygdala, contains a high density endocannabinoid receptor CB1. To elucidate role system learning, we tested influence acute chronic administration agonists (THC, WIN55,212-2) antagonists (Rimonabant, AM-281) on two different paradigms. appetitively motivated two-alternative choice paradigm, animals learned associate certain color with food reward. second set-up, fish shuttle-box, associated onset light stimulus occurrence subsequent electric shock (avoidance conditioning). Once successfully had solve these behavioral tasks, activation or inactivation no effect memory retrieval, suggesting that established memories were stable not alterable by system. both treatment improved acquisition additionally facilitated reversal during discrimination. contrast, CB1 prevented aversively while effects found learning. While THC significantly performance, WIN55,212-2 impaired association. Our findings suggest can modulate Stimulation might play more specific storage aversive memory, blocking induces general enhancement cognitive functions.