Short-term Effects of Pitavastatin on Biochemical Markers of Bone Turnover in Patients with Hypercholesterolemia

摘要: Object No consensus has been reached whether clinical use of statins beneficial effects on bone health, partly due to lower statin concentrations because first-pass metabolism by the liver. We thus evaluated pitavastatin, which does not undergo metabolism, metabolism. Methods According therapeutic regimen, subjects were divided into two groups (group A, 66 with pitavastatin; group B, 35 without pitavastatin). Bone-specific alkaline phosphatase (BAP) and serum N-terminal telopeptide type I collagen (NTx) as turnover markers (BTMs) compared between at baseline after 3 months treatment in each group. Correlations characteristics ΔBTMs, Δlipid profile ΔBTMs investigated using both Pearson's correlation analysis multivariate analysis. Patients The 101 patients untreated hypercholesterolemia. Results After treatment, BAP A did change significantly either value or that B. However, NTx decreased In addition, ΔNTx was negatively correlated baseline, significance this persisted multiple regression Conclusion Our findings suggest pitavastatin may have potentially primarily reducing resorption rather than stimulating formation. Further studies more longer duration are warranted evaluate its effects, if any, prevention osteoporosis subsequent fractures.