Pluronic lecithin organogel as a topical drug delivery system.
作者： Mohit Pandey , Veena Belgamwar , Surendra Gattani , Sanjay Surana , Avinash Tekade
DOI: 10.3109/10717540903508961
关键词:
摘要: The objective of this study was to formulate and evaluate the pluronic lecithin organogel containing flurbiprofen for topical application. Different formulations organogels were prepared by using F127, lecithin, flurbiprofen, isopropyl palmitate, water, sorbic acid, potassium sorbate. To in vitro potential these formulations, permeation studies performed with Keshary-Chien diffusion cells. results found that release from dialysis membrane-70 more than excised dorsal rat skin. Gelation temperature carried out determine where sol-gel transformation takes place. viscosities different determined Brookfield Viscometer at 25°C, viscosity increases as concentration increases. Also tested appearance feel psychorheologically, pH, drug content. Interactions between components gel have been investigated differential scanning calorimetry X-ray powder diffractometry. optimized formulation subjected shows no drug-polymer interaction. investigate vivo performance a carrageenan-induced paw edema model skin irritation used. stability freeze-thaw thermal cyclic test out, showing phase separation gel, representing stability. Statistical analysis data animal (anti-inflammatory activity) done one way variance (ANOVA) followed Dunnett's test. statistically significant anti-inflammatory activity is non-irritant
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