After Intracerebral Hemorrhage, Oligodendrocyte Precursors Proliferate and Differentiate Inside White-Matter Tracts in the Rat Striatum.

摘要: Damage to myelinated axons contributes neurological deficits after acute CNS injury, including ischemic and hemorrhagic stroke. Potential treatments promote re-myelination will require fully differentiated oligodendrocytes, but almost nothing is known about their fate following intracerebral hemorrhage (ICH). Using a rat model of ICH in the striatum, we quantified survival, proliferation, differentiation oligodendrocyte precursor cells (OPCs) (at 1, 3, 7, 14, 28 days) peri-hematoma region, surrounding contralateral striatum. In peri-hematoma, density Olig2+ increased dramatically over first 7 days, this coincided with disorganization fragmentation axon bundles. Very little proliferation (Ki67+) was seen anterior subventricular zone from 1 28 days. However, by 3 days, many were proliferating suggesting that local expands population. By 14 days, declined and, 28 days, it reached low level At these later times, surviving aligned into white-matter bundles, which appeared less swollen or fragmented. Oligodendrocyte cell maturation prevalent 28-day period. Densities immature OPCs (NG2+Olig2+) mature (CC-1+Olig2+) oligodendrocytes week. Regardless state, they preferentially inside These results provide evidence endogenous precursors proliferate differentiate region have potential re-myelinate tracts