Current and future biomarkers in gastric cancer
作者： Muhammad Abbas , Alessia Faggian , Dahiru Nasiru Sintali , Ghulam Jilany Khan , Shagufta Naeem
DOI: 10.1016/J.BIOPHA.2018.04.178
关键词:
摘要: Gastric cancer is the fourth most common worldwide cause of cancer-related death. Early gastric has no associated symptoms, for this reason, patients come to attention clinicians only in advanced stages. This paper aims give a global view on biomarkers and therapy use. We discuss VEGF family, HER E-cadherin, PD-L1, PD-L2, FGFR, mTOR. Finally, we considered emerging as MET, microsatellite instability, microRNA variations. Furthermore, have analyzed depth chemotherapeutic adjuvant therapies used clinic nowadays, comparing overall progression-free survival between them. Identifying validating diagnostic, prognostic, predictive, pharmacodynamic will be mandatory huge impact patients' outcomes improving efficiency drug development process.
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