Heart failure with preserved ejection fraction.

摘要: Many patients with heart failure (HF) have a normal left ventricular ejection fraction, and are labelled as having HF preserved fraction (HFPEF). Hypertension, atrial fibrillation age important contributors to the development of HFPEF and, therefore, its prevalence is likely increase in next few decades. The pathophysiology heterogeneous but final common pathway leading congestion. remains clinical diagnosis plasma concentration B-type natriuretic peptide (eg BNP/N-terminal prohormone BNP (NT-proBNP)), marker congestion, an essential component. Imaging, usually by echocardiography, required determine cardiac phenotype (ie valve disease, fraction) underlying HF. A superficially echocardiogram does not exclude No treatment has been shown conclusively alter prognosis HFPEF. However, treatments directed at congestion hypertension, such diuretics, mineralocorticoid receptor antagonists (MRAs) angiotensin converting-enzyme inhibitors, may improve symptoms probably do outcomes. yet reverse myocardial pathology HFPEF, although there some hope that MRAs might.