Serum interleukin 2 receptor levels in childhood acute lymphoblastic leukemia.

摘要: The clinical significance of interleukin 2 receptor (IL2R) concentrations in serum was determined for 344 children with newly diagnosed acute lymphoblastic leukemia (ALL). Serum levels IL2R patients (267 to 80,000 U/mL, median 2,007 U/mL) were significantly higher than normal control values (170 738 347 (P less .0001). Measurements cases T cell ALL lower the non-T, non-B = .02). Among 264 ALL, but not those disease, (greater 2,000 associated a poorer treatment outcome .04). In multivariate analysis, level contributed independent prognostic information beyond that conveyed by leukocyte count, race, and age One explanation these results is soluble competes lymphocyte-integrated ligand thus could suppress host antitumor immunity.