Antineutrophil cytoplasmic autoantibody testing in vasculitides.

摘要: This article summarizes the most recent findings concerning clinical relevance of antineutrophil cytoplasmic autoantibody (ANCA) testing for patients with idiopathic vasculitis and diseases known to be associated secondary vasculitis. The value granular pattern (c)ANCA (proteinase 3 [PR3]-ANCA) perinuclear fluorescence (p)ANCA (myeloperoxidase [MPO]-ANCA) in Wegener's granulomatosis (WG) microscopic polyangiitis (MPA), respectively, is now well established; however, various subspecificities beside myeloperoxidase (MPO), which also include staining pattern, are detectable not only vasculitis, but equally a heterogeneous patient population spectrum autoimmune chronic inflammatory bowel, liver, so forth. Future studies must establish specificity, sensitivity, role these pANCA usually measured by enzyme-linked immunosorbent assays distinct disease entities medicine. In summary, despite relatively poor understanding immunopathogenesis ANCA-associated disease, cANCA (PR3-ANCA) (MPO-ANCA) continue important markers so-called "ANCA-associated vasculitides" (i.e., WG, MPA, Churg-Strauss syndrome).