Comparison of paracentesis and diuretics in the treatment of cirrhotics with tense ascites. Results of a randomized study.

作者: Pere Ginés , Vicente Arroyo , Enrique Quintero , Ramón Planas , Felipe Bory

DOI: 10.1016/0016-5085(87)91007-9

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摘要: To investigate whether paracentesis could be an alternative therapy for ascites, 117 cirrhotics with tense ascites were randomly allocated into two groups. Fifty-eight patients (group 1) treated (4-6 L/day until disappearance of ascites) and intravenous albumin infusion (40 g after each tap). Fifty-nine 2) spironolactone (200-400 mg/day) plus furosemide (40-240 mg/day). Patients from group 2 not responding to diuretics a LeVeen shunt. After both groups discharged hospital instructed take diuretics. developing during follow-up readmitted according their initial schedule. Paracentesis was effective in eliminating the 56 1 (96.5%) did induce significant changes renal hepatic function, plasma volume, cardiac index, peripheral resistance, renin activity, norepinephrine antidiuretic hormone concentration, urinary excretion prostaglandin E2 6-keto-prostaglandin F1 alpha. Diuretics 43 (72.8%) (p less than 0.05). Ten 36 developed complications first stay 0.001). This difference due significantly higher incidence encephalopathy, impairment, electrolyte disturbances occurring The duration 11.7 +/- 1.5 days 31 2.8 differ respect probability requiring readmission follow-up, reasons readmission, survival entry study, causes death. These results indicate that associated is fast, effective, safe cirrhosis.

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