Time trend and the age-period-cohort effect on the incidence of histologic types of lung cancer in connecticut, 1960-1989

摘要: Background. Recent epidemiologic studies have suggested changing patterns of lung cancer incidence by histologic type. The observed time trends been attributed to a change in the rate cigarette smoking, changes exposure new environmental carcinogens, and criteria for histopathologic diagnosis cancer. current study was designed examine type Connecticut use this information project future trend disease population. Methods. This based on all cases reported Tumor Registry between 1960 1989. On basis data set, crude age-adjusted rates were calculated each sex. age-specific are presented calendar year cohort birth. A regression model used identify birth cohort, period, age as determinants trends. Results. For overall rates, squamous cell carcinoma small stabilized men, whereas they still increasing women. adenocarcinoma has both men women, but there much sharper among females since mid1970s. An examination results from age-period-cohort modeling indicate that incidences three major types recent cohorts either started decreasing (squamous carcinoma) or shown clear reduction increase (adenocarcinoma carcinoma). study, however, did not an bronchoalveolar carcinoma, which other clinically studies. Conclusion. While showed different cancer, males females. pattern is consistent with smoking over including prevalence consumption low tar filter cigarettes. It expected if tobacco continues no risk factors forthcoming stabilization decrease (including adenocarcinoma) sexes could be anticipated.