THE IMPACT OF DIABETES MELLITUS ON SKELETAL MUSCLE MASS AND STRENGTH IN OLDER ADULTS

摘要: In older adults, diabetes is a serious public health problem because of high prevalence as well its devastating consequences such functional disability and mortality. Loss muscle mass strength, called sarcopenia, has been considered common pathway leading to loss function frailty in adults. We investigated the impact on skeletal strength 3,075 adults aged 70 79, enrolled Health, Aging Body Composition Study. Diabetes was defined not only by self report or medication use, but also fasting plasma glucose result 75-g oral challenge test. Muscle measured state art techniques dual-energy X-ray absorptiometry (DXA) computed tomography (CT). assessed quantitatively isometric isokinetic dynamometers. quality maximal per unit mass. cross-sectional study, we found that significantly lower men with higher women despite having greater than those without diabetes. consistently both non-diabetic counterparts upper extremities. longer duration (greater equal 6 yrs) poor glycemic control (A1c > 8.0 %) were associated even quality. longitudinal showed about 50% declines leg compared Leg declined more rapidly Skeletal mass, estimated DXA, Interestingly, pronounced undiagnosed Thigh area CT two times faster either diagnosed women. The importance these findings clearly risk factor for need develop strategy prevent rapid this population.