Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum.
作者： Xiaoqun Gao , Cheng Chang , Jiewen Zhang , Yue Huang
DOI: 10.3969/J.ISSN.1673-5374.2012.34.002
关键词:
摘要: Previous studies showed that tyrosine hydroxylase or neurturin gene-modified cells transplanted into rats with Parkinson’s disease significantly improved behavior and increased striatal dopamine content. In the present study, we bone marrow-derived mesenchymal stem damaged striatum of model rats. Several weeks after cell transplantation, in addition to an improvement motor function, proteins were up-regulated injured striatum, importantly, levels its metabolite 3,4-dihydroxyphenylacetic acid significantly. Furthermore, density D2 receptor postsynaptic membranes dopaminergic neurons was decreased. These results indicate transplantation increases synthesis improves disease.
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