From counting neurons to the preclinical diagnosis of Alzheimer's disease.

作者: Christian Bancher

DOI: 10.3233/JAD-2001-3109

关键词:

摘要: This article is a review of scientific work on Alzheimer neurofibrillary degeneration and Ass-amyloidosis that was done in collaboration with Dr. Henryk Wisniewski, part at the Institute for Basic Research Developmental Disabilities. Our paired helical filaments tau protein spans from basic immunocytochemical analyses brain tissue to clinical application as biological marker used diagnostic tests. Even though only small Wisniewski's oeuvre, these data illustrate how great scientist opens field his student, collaborator friend, science can evolve, results be applied practice benefit our patients.

参考文章(31)
C. Bancher, K. Jellinger, I. Wichart, Biological markers for the diagnosis of Alzheimer’s disease Journal of Neural Transmission. Supplementa. ,vol. 53, pp. 185- 197 ,(1998) , 10.1007/978-3-7091-6467-9_17
N. Rösler, I. Wichart, C. Bancher, K. A. Jellinger, Tau protein and apolipoprotein E in CSF diagnostics of Alzheimer’s disease: impact on non Alzheimer’s dementia? Journal of Neural Transmission Supplement. ,vol. 47, pp. 259- 266 ,(1996) , 10.1007/978-3-7091-6892-9_18
I Grundke-Iqbal, G P Wang, K Iqbal, H M Wisniewski, Laboratory diagnostic tests for Alzheimer's disease. Progress in Clinical and Biological Research. ,vol. 317, pp. 679- 687 ,(1989)
I Grundke-Iqbal, K Iqbal, M Quinlan, Y C Tung, M S Zaidi, H M Wisniewski, Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. Journal of Biological Chemistry. ,vol. 261, pp. 6084- 6089 ,(1986) , 10.1016/S0021-9258(17)38495-8
NikolaosK. Robakis, HenrykM. Wisniewski, EdmundC. Jenkins, EvelynA. Devine-Gage, GeorgeE. Houck, Xiu-Lan Yao, Narayanarao Ramakrishna, Gloria Wolfe, WayneP. Silverman, W. Ted Brown, Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. The Lancet. ,vol. 329, pp. 384- 385 ,(1987) , 10.1016/S0140-6736(87)91754-5
M BARCIKOWSKA, HM WISNIEWSKI, C BANCHER, KS KIM, GY WEN, J CURRIE, Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease. Acta Neuropathologica. ,vol. 78, pp. 337- 347 ,(1989) , 10.1007/BF00688170
John P. Blass, Kwan-Fu Rex Sheu, Li-wen Ko, Christian L. Bancher, Henryk M. Wisniewski, Margaret Bouvier, Janet T. Duffy, Andrea C. Baker, Presence of low amounts of "neuronal" antigens in cultured human skin fibroblasts. Journal of the Neurological Sciences. ,vol. 107, pp. 223- 232 ,(1992) , 10.1016/0022-510X(92)90293-T
Hans Lassmann, Christian Bancher, Helene Breitschopf, Jerzy Wegiel, Maciej Bobinski, Kurt Jellinger, Henryk M. Wisniewski, Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ Acta Neuropathologica. ,vol. 89, pp. 35- 41 ,(1995) , 10.1007/BF00294257
HENRYK M. WISNIEWSKI, PATRICIA A. MERZ, KHALID IQBAL, Ultrastructure of Paired Helical Filaments of Alzheimer's Neurofibrillary Tangle Journal of Neuropathology and Experimental Neurology. ,vol. 43, pp. 643- 656 ,(1984) , 10.1097/00005072-198411000-00008
Henryk M. Wisniewski, C Bancher, Hans Lassmann, Herbert Budka, Kurt Jellinger, Inge Grundke-Iqbal, Khalid Iqbal, G Wiche, Franz Seitelberger, An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. Journal of Neuropathology and Experimental Neurology. ,vol. 48, pp. 81- 93 ,(1989) , 10.1097/00005072-198901000-00007