The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression
作者： Grażyna Jurkowska , Grażyna Piotrowska-Staworko , Katarzyna Guzińska-Ustymowicz , Andrzej Kemona , Agnieszka Świdnicka-Siergiejko
DOI: 10.1016/J.ADVMS.2014.01.006
关键词:
摘要: Abstract Purpose Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role carcinogenesis. We assessed if infection eradication Helicobacter pylori ( H. ) affects factors serum gastrin concentrations. Patients/methods examined immunohistochemically both receptors’ in: cancer (GC; n = 29), chronic gastritis (GHp+; = 40) before after patients without (GHp−; = 42). Results Before therapy, mucosal receptor's expressions GHp+ were increased compared to GHp− p Conclusions In EGF, EGFR, are similar those observed cancer. The persistence antral receptors eradication, at level comparable group, suggests their eventual progression changes initiated by toward
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