Asymmetric Distribution of Glucose Transporter mRNA Provides Growth Advantage

摘要: Asymmetric localization of mRNA is important for cell fate decisions in eukaryotes and provides the means localized protein synthesis a variety types. Here we show that hexose transporter mRNAs are retained mother S. cerevisiae until metaphase-anaphase transition (MAT) then released into bud. The was translationally inactive but bound to ribosomes before MAT. Importantly, when cells were shifted from starvation glucose-rich conditions, HXT2 mRNA, none other HXT mRNAs, enriched bud after This enrichment dependent on Ras/cAMP/PKA pathway, APC ortholog Kar9 nuclear segregation Competition experiments between strains only expressed one at time revealed grow faster than their counterparts starvation. Therefore, asymmetric distribution growth advantage young daughters, who better prepared nutritional changes environment. Our data provide evidence an factor determining cellular fitness.