Hybrid human/rodent igg antibody to cd3, and methods of its construction

摘要: An IgG antibody is provided having a binding affinity for the CD3 antigen complex in which heavy chain has variable region framework together with at least one CDR selected from amino acid sequences of SEQ ID No 2, 4 and 6 respective conservatively modified variants thereof light 8, 10 12 characterised that corresponds sequence to human type includes or more specific acids characteristic rodent sequence. The novel capable being expressed by mammalian cell expression systems enhanced yields.