Inhibition of gastric emptying is a physiological action of cholecystokinin.

摘要: Abstract This study was designed to determine whether cholecystokinin (CCK) plays a physiological role in the inhibition of gastric emptying. Physiological conditions were simulated by giving CCK continuous intravenous infusion rather than bolus injection, using doses known be distinctly submaximal for pancreatic protein secretion and gallbladder contraction, releasing endogenous CCK. The rate emptying determined 4 dogs with fistulas measuring volume fluid remaining stomach 10 min after instillation 300 ml 0.15 m NaCl. Rate studied during saline (control) different 98% pure CCK, commerically available 20% synthetic COOH-terminal octapeptide (OP-CCK), pentagastrin, heptadecapeptide gastrin. effect endogenously released solutions which concentrations tryptophan replaced equiosmolar amounts D 50 's (3 U kg -1 hr ) OP-CCK (125 ng about same as their cholecystokinetic pancreozyminic actions. By contrast, although both pentagastrin gastrin inhibited emptying, required this action much higher stimulation acid secretion. effectiveness indicates that is attributable itself not an impurity preparation. We have confirmed directly showing potent inhibitor Tryptophan also In other contraction shown stimulated time inhibiting evidence supports view one actions but case it must regarded pharmacological action.