2-alkylidene-18,19-dinor-vitamin D compounds
作者： Hector F. Deluca , Rafal R. Sicinski , Rafal Barycki , Lori A. Plum , Pawel K. Grzywacz
DOI:
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摘要: 2-alkylidene-18,19-dinor-vitamin D compounds are disclosed as well pharmaceutical uses for these and methods of synthesizing compounds. These characterized by low bone calcium mobilization activity high intestinal transport activity. This results in novel therapeutic agents the treatment prophylaxis diseases where formation is desired, particularly osteoporosis, autoimmune such multiple sclerosis, diabetes mellitus lupus. also exhibit pronounced arresting proliferation undifferentiated cells inducing their differentiation to monocyte thus evidencing use an anti-cancer agent skin psoriasis. increase both breaking strength crushing bones conjunction with replacement surgery hip knee replacements.
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