Fc receptor-induced expression of fas ligand on activated NK cells facilitates cell-mediated cytotoxicity and subsequent autocrine NK cell apoptosis

摘要: Ligation of the Fc gamma R on NK cells by Ab-coated target initiates a mode killing referred to as antibody-dependent cell-mediated cytotoxicity (ADCC). There is clear evidence that release from granules containing pore-forming proteins and serine proteases can result in rapid (within minutes) cell death targets. However, little information available whether initiate subsequent through granule-independent mechanisms down-regulate responses. We demonstrate this study FcR stimulation activated human not only induces granule exocytosis, but also subsequently results transcriptional up-regulation Fas ligand. These FcR-stimulated then kill targets bear (CD95/APO-1), be inhibited blocking Abs receptor. In addition, resting become activated, their receptors competent deliver autocrine suicide signals. work interaction ligand with apoptosis cells. suggest FcR-induced expression critically influence capacity these mediate paracrine death.