The Role of Ultrasound-Driven Microbubble Dynamics in Drug Delivery: From Microbubble Fundamentals to Clinical Translation
作者： Silke Roovers , Tim Segers , Guillaume Lajoinie , Joke Deprez , Michel Versluis
DOI: 10.1021/ACS.LANGMUIR.8B03779
关键词:
摘要: In the last couple of decades, ultrasound-driven microbubbles have proven excellent candidates for local drug delivery applications. Besides being useful carriers, demonstrated ability to enhance cell and tissue permeability and, as a consequence, uptake herein. Notwithstanding large amount evidence their therapeutic efficacy, open issues remain. Because vast number ultrasound- microbubble-related parameters that can be altered variability in different models, translation from basic research (pre)clinical studies has been hindered. This review aims at connecting knowledge gained fundamental microbubble efficacy seen vitro vivo studies, with an emphasis on better understanding response upon exposure ultrasound its interaction cells tissues. More specifically, we address acoustic settings (i.e., bubble size a...
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