Differential cell-matrix responses in hypoxia-stimulated aortic versus mitral valves.

摘要: Tissue oxygenation often plays a significant role in disease and is an essential design consideration for tissue engineering. Here, oxygen diffusion profiles of porcine aortic mitral valve leaflets were determined using chamber conjunction with computational models. Results from these studies revealed the differences between leaflet suggested that alone was insufficient normal delivery valves. During fibrotic disease, thickening due to abnormal extracellular matrix likely reduce regional availability. To assess impact low levels on behaviour, whole organ cultures created induce hypoxia. These loss layer stratification elevated hypoxia inducible factor 1-alpha both hypoxic groups. Mitral valves also exhibited altered expression angiogenic factors response environments when compared normoxic Hypoxia affected differently, appeared show stenotic, rheumatic phenotype accompanied by cell death. results indicate could be mid late progression, especially reduction chondromodulin-1 shown