Behavior of spinal neurons deprived of supraspinal input.

摘要: This Review discusses the spinal neuronal changes that occur after a complete cord injury (SCI) in humans. Early an SCI, neither locomotor nor reflex activity can be evoked. Once shock has resolved, and early component reappear response to appropriate peripheral afferent input. In subsequent 4-8 months, clinical signs of spasticity appear, largely as result non-neuronal (for example, muscular) changes, whereas undergo little change. At 9-12 electromyographic amplitude leg muscles during assisted locomotion declines, accompanied by decrease increase late component. exhaustion also occurs nonambulatory patients with incomplete SCI. Neuronal dysfunction is fully established 1 year without further alterations years. chronic absence input from supraspinal sources been suggested lead degradation function below level lesion or, alternatively, predominance inhibitory signaling pattern generator. Appropriate training and/or provision neurons might help prevent