L-Methionase: A Therapeutic Enzyme to Treat Malignancies

摘要: Cancer is an increasing cause of mortality and morbidity throughout the world. L-methionase has potential application against many types cancers. L-Methionase intracellular enzyme in bacterial species, extracellular fungi, absent mammals. producing strain(s) can be isolated by 5,5′-dithio-bis-(2-nitrobenzoic acid) as a screening dye. L-Methionine plays important role tumour cells. These cells become methionine dependent eventually follow apoptosis due to limitation cancer also indispensable gene activation inactivation hypermethylation and/or hypomethylation. Membrane transporters such GLUT1 ion channels like Na2+, Ca2+, K+, Cl− overexpressed. Further, α-subunit ATP synthase growth development providing them enhanced nutritional requirements. Currently, selenomethionine used prodrug therapy along with methionase that converts into active toxic chemical(s) causes death cancerous cells/tissue. More recently, fusion protein (FP) consisting linked annexin-V been therapy. The proteins have advantage they specificity only for do not harm normal