Controlled evaluation of three drug combination regimens versus fluorouracil alone for the therapy of advanced gastric cancer. North Central Cancer Treatment Group.

摘要: PURPOSEThe purpose of this study was to evaluate the therapeutic effectiveness fluorouracil (5-FU), doxorubicin, and methyl lomustine (CCNU) (FAMe), 5-FU, cisplatin (FAP), FAMe alternating with triazinate (TZT) when compared a standard therapy 5-FU alone in patients advanced gastric cancer.PATIENTS AND METHODSTwo hundred fifty-two eligible selected for had proven locally unresectable and/or metastatic adenocarcinoma. The majority nonmeasureable disease. They were randomly assigned receive one three drug combination regimens or administered by rapid injection 5-day course. Survival primary end point.RESULTSNone combinations showed significant advantage over improved performance score, weight gain, patient survival. Each more toxic than alone.CONCLUSIONFAMe, FAP, TZT cannot be recommended a...