Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.
作者： David J. Maloney , Jerry L. Nadler , David A. Taylor-Fishwick , Jessica Weaver , Lindsey Glenn
DOI: 10.1007/S00125-014-3452-0
关键词:
摘要: Aims/hypothesis Islet inflammation leads to loss of functional pancreatic beta cell mass. Increasing evidence suggests that activation 12-lipoxygenase inflammatory loss. This study evaluates new specific small-molecule inhibitors for protecting rodent and human cells from damage.
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