Gabapentin misuse, abuse and diversion: a systematic review

摘要: Background and Aims Since its market release, gabapentin has been presumed to have no abuse potential subsequently prescribed widely off-label, despite increasing reports of misuse. This review estimates describes the prevalence effects of, motivations behind, risk factors for misuse, abuse, diversion. Methods Databases were searched peer-reviewed articles demonstrating characterized by taking a larger dosage than or without prescription, All types studies considered; grey literature was excluded. Thirty-three met inclusion criteria, consisting 23 case 11 epidemiological reports. Published came from USA, UK, Germany, Finland, India, South Africa, France, two analyzed websites not specific particular country. Results Prevalence misuse in general population reported be 1%, 40-65% among individuals with prescriptions, between 15-22% within populations people who opioids. An array subjective experiences reminiscent opioids, benzodiazepines, psychedelics over range doses, including those clinical recommendations. Gabapentin primarily misused recreational purposes, self-medication, intentional self-harm alone combination other substances, especially and/or alcohol. Individuals histories drug most often involved Conclusions Epidemiological report evidence suggests that antiepileptic analgesic medication is being internationally at rate about substance special misuse/abuse. Language: en