Intestinal Perforation in Typhoid Fever: A Historical and State-of-the-Art Review

摘要: The appropriate therapy for intestinal perforation in typhoid fever has been controversial since the late 1880s. Around turn of century, surgery became established mode therapy, with a mortality 69% based on 166 patients English-language medical literature, and continued to be preferred treatment until advent chloramphenicol 1948. At this time surgical was approximately 50%. Following recovery few treated only antimicrobial agents (six initially, then eventually 22), nonsurgical accepted treatment. This change never justified review demonstrates this. Appropriate is virtually always surgical, usually consisting simple closure irrigation. Chloramphenicol alone inadequate patient must supplemented by other antimicrobials directed against enteric aerobic gram-negative bacilli anaerobes.