Comprehensive kinetics of triiodothyronine production, distribution, and metabolism in blood and tissue pools of the rat using optimized blood-sampling protocols.
作者： JOSEPH J. DISTEFANO , M. JANG , T. K. MALONE , M. BROUTMAN
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摘要: We have determined estimates for 24 physiological parameters of production, interpool transport, distribution, and metabolism T3 in the major pools unanesthetized male Sprague-Dawley rat, from blood-borne data a comprehensive model analysis this system. Most these indices previously been unavailable. Whereas only 3% (2 ng/100 g BW) total body pool (74 is plasma, composite slowly equilibrating (slow) tissue (e.g. muscle, skin, brain) appears to contain most T3, 76% (57 total. The rapidly (fast) liver kidney) contains remaining 19% (16 BW). production rate 0.12 BW·min, we estimate that about half emanates directly T4 slow pools, whereas remainder derived both thyroidal secretion conversion fast pools. Our results also indicate molecules spend an average...
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