RP-HPTLC RETENTION DATA IN CORRELATION WITH THE IN-SILICO ADME PROPERTIES OF A SERIES OF S-TRIAZINE DERIVATIVES

摘要: The properties relevant to pharmacokinetics and pharmacodynamics of four series synthesized s-triazine derivatives have been studied by Quantitative structureretention relationship (QSRR) approach. chromatographic behavior these compounds was investigated using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (R M 0 ) correlated with selected physicochemical parameters pharmacokinetics, i.e. ADME (absorption, distribution, metabolism excretion). In addition, the ability act as kinase inhibitors protease predicted for all triazine classes. Also, in order confirm similarities/dissimilarities between examined compounds, principal component analysis (PCA) based on calculated conducted. R values recommended description evaluation pharmacokinetic properties. According results this study, meet criteria preselection drug candidates.