Selective ablation of neurons by methylazoxymethanol during pre- and postnatal brain development

摘要: Neonatal or pregnant albino rats were injected with either single double doses of methylazoxymethanol (20 mg/kg) to test the temporal specificity its effect on clearly definable regions brain. A dose, dams from gestational day 11 21 (G11-G21) and neonatal birth postnatal 5 (P0-P5), produced differential weight reductions among various brain regions. Two prominent peaks reduction found: one occurring between G13 G15 for cerebrum hippocampus P0 P1 cerebellum olfactory bulbs. Dual injections drug G14 60% in cerebrum, slightly earlier reduced by about 23%. This was accompanied narrowing cerebellar width, which we believe due fewer Purkinje cells. at bulb 65%, 62%, 18%. These results show that short action is within window cell division neurons becomes additive two successive days. precise toxic development can be used disproportionally reduce number neuroblasts specific ablation allows analysis plasticity pyramidal nonpyramidal cells neocortex hippocampus, granule cerebellum, mitral