Preoperative radiochemotherapy in the treatment of advanced oral cancer: Outcome of 276 patients
作者： Clemens Klug , Dominik Berzaczy , Martin Voracek , Christina Nell , Oliver Ploder
DOI: 10.1016/J.JCMS.2008.11.012
关键词:
摘要: Summary Introduction The aim of this study was to review survival and locoregional control in patients with advanced oral oropharyngeal squamous cell carcinoma treated by multimodal therapy preoperative radiochemotherapy radical surgery. Material Retrospective cohort study. Methods Included analysis are 276 consecutive UICC disease stages III IV (T2: 13.0%; T3: 16.7%; T4: 70.3%; N0: 29.7%; N1: 20.3%; N2: 45.3%; N3: 4.7%; stage III: 16.3%; IV: 83.7%). All received (50 Gy, Mitomycin 5-Fluorouracil) resection. Results Median surveillance period 101.4 months (24–202 months). 5-year overall probability 53.9%. local 70.2%. Conclusion These results underline the reliability treatment cancer.
elsevier.com
sci-hub.se 参考文章(12)
Tanguy Y Seiwert, Joseph K Salama, Everett E Vokes, The chemoradiation paradigm in head and neck cancer. Nature Reviews Clinical Oncology. ,vol. 4, pp. 156- 171 ,(2007) , 10.1038/NCPONC0750
Rainer Schmelzeisen, Friedrich Wilhelm Neukam, Tatsuo Shirota, Burkhard Specht, Mathias Wichmann, Postoperative function after implant insertion in vascularized bone grafts in maxilla and mandible. Plastic and Reconstructive Surgery. ,vol. 97, pp. 719- 725 ,(1996) , 10.1097/00006534-199604000-00005
C. Klug, A. Wutzl, C. Kermer, M. Voracek, G. Kornek, E. Selzer, C. Glaser, P.W. Poeschl, W. Millesi, R. Ewers, Preoperative radiochemotherapy and radical resection for stages II-IV oral and oropharyngeal cancer: outcome of 222 patients. International Journal of Oral and Maxillofacial Surgery. ,vol. 34, pp. 143- 148 ,(2005) , 10.1016/J.IJOM.2004.04.003
C. Klug, A. Wutzl, C. Kermer, O. Ploder, I. Sulzbacher, E. Selzer, M. Voracek, M. Oeckher, R. Ewers, W. Millesi, Preoperative radiochemotherapy and radical resection for stages II to IV oral and oropharyngeal cancer: grade of regression as crucial prognostic factor. International Journal of Oral and Maxillofacial Surgery. ,vol. 34, pp. 262- 267 ,(2005) , 10.1016/J.IJOM.2004.04.004
Joseph K. Salama, Tanguy Y. Seiwert, Everett E. Vokes, Chemoradiotherapy for Locally Advanced Head and Neck Cancer Journal of Clinical Oncology. ,vol. 25, pp. 4118- 4126 ,(2007) , 10.1200/JCO.2007.12.2697
Ch. Mohr Doz., W. Bohndori, J. Carstens, F. Härle, J.E. Hausamen, H. Hirche, H. Kimmig, J. Kutzner, J. Mühling, J. Reuther, H. Sack, D. Schettler, R. Stellmach, W. Wagner, M.F. Wannenmacher, Preoperative radiochemotherapy and radical surgery in comparison with radical surgery alone. A prospective, multicentric, randomized DÖSAK study of advanced squamous cell carcinoma of the oral cavity and the oropharynx (a 3-year follow-up) International Journal of Oral and Maxillofacial Surgery. ,vol. 23, pp. 140- 148 ,(1994) , 10.1016/S0901-5027(05)80288-7
M.G. McGurk, K.F.M. Fan, A.D. MacBean, V. Putcha, Complications encountered in a prospective series of 182 patients treated surgically for mouth cancer. Oral Oncology. ,vol. 43, pp. 471- 476 ,(2007) , 10.1016/J.ORALONCOLOGY.2006.04.017
Simon Florian Preuss, Vera Dinh, Jens Peter Klussmann, Robert Semrau, Rolf-Peter Mueller, Orlando Guntinas-Lichius, Outcome of multimodal treatment for oropharyngeal carcinoma : A single institution experience Oral Oncology. ,vol. 43, pp. 402- 407 ,(2007) , 10.1016/J.ORALONCOLOGY.2006.04.015
Clemens Klug, Dominik Berzaczy, Martin Voracek, Georg Enislidis, Thomas Rath, Werner Millesi, Rolf Ewers, Experience with microvascular free flaps in preoperatively irradiated tissue of the oral cavity and oropharynx in 303 patients. Oral Oncology. ,vol. 41, pp. 738- 746 ,(2005) , 10.1016/J.ORALONCOLOGY.2005.03.015
Batya R. Goldwaser, Sung-Kiang Chuang, Leonard B. Kaban, Meredith August, Risk factor assessment for the development of osteoradionecrosis. Journal of Oral and Maxillofacial Surgery. ,vol. 65, pp. 2311- 2316 ,(2006) , 10.1016/J.JOMS.2007.05.021