PLASMA MEMBRANE CA2+-PUMP FUNCTIONAL SPECIALIZATION IN THE BRAIN: COMPLEX OF ISOFORM EXPRESSION AND REGULATION BY EFFECTORS
作者： Ján Lehotský
DOI: 10.1007/BF02960911
关键词:
摘要: The plasma membrane Ca2+-pump (PMCA) is a key element in the removal of intracellular Ca2+. A number PMCA pumps, encoded by multigenic family and differing their regulatory domains, also exist neuronal cells. We discuss here an idea regarding new, higher level specialization protein isoforms with different sensitivities toward phospholipids calmodulin. based on kinetic data from stimulation acidic phospholipids, combination results describing alternative RNA splicing at site C coding domains protein. resulting complex modulation underlies specific cellular requirements for Ca2+ homeostasis tissue-selective manner regulated spatial distribution enzyme as well factors. possible role injury discussed.
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Akhlaq A. Farooqui, Yutaka Hirashima, Tahira Farooqui, Lloyd A. Horrocks, INVOLVEMENT OF CALCIUM, LIPOLYTIC ENZYMES, AND FREE FATTY ACIDS IN ISCHEMIC BRAIN TRAUMA Springer, Boston, MA. pp. 117- 138 ,(1992) , 10.1007/978-1-4615-3312-2_7
G Hakim, T Itano, A K Verma, J T Penniston, Purification of the Ca2+-and Mg2+-requiring ATPase from rat brain synaptic plasma membrane. Biochemical Journal. ,vol. 207, pp. 225- 231 ,(1982) , 10.1042/BJ2070225
Frank Wuytack, Luc Raeymaekers, The Ca(2+)-transport ATPases from the plasma membrane. Journal of Bioenergetics and Biomembranes. ,vol. 24, pp. 285- 300 ,(1992) , 10.1007/BF00768849
Troy T. Rohn, Thomas R. Hinds, Frank F. Vincenzi, Ion transport ATPases as targets for free radical damage: Protection by an aminosteroid of the Ca2+ pump atpase and Na+/K+ pump ATPase of human red blood cell membranes Biochemical Pharmacology. ,vol. 46, pp. 525- 534 ,(1993) , 10.1016/0006-2952(93)90530-A
A.K. Grover, I. Khan, Calcium pump isoforms: diversity, selectivity and plasticity. Review article. Cell Calcium. ,vol. 13, pp. 9- 17 ,(1992) , 10.1016/0143-4160(92)90025-N
A.G. Filoteo, A Enyedi, J.T. Penniston, The lipid-binding peptide from the plasma membrane Ca2+ pump binds calmodulin, and the primary calmodulin-binding domain interacts with lipid. Journal of Biological Chemistry. ,vol. 267, pp. 11800- 11805 ,(1992) , 10.1016/S0021-9258(19)49769-X
T H Kuo, K K Wang, L Carlock, C Diglio, W Tsang, Phorbol ester induces both gene expression and phosphorylation of the plasma membrane Ca2+ pump Journal of Biological Chemistry. ,vol. 266, pp. 2520- 2525 ,(1991) , 10.1016/S0021-9258(18)52275-4
P Brandt, R.L. Neve, A Kammesheidt, R.E. Rhoads, T.C. Vanaman, Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. Journal of Biological Chemistry. ,vol. 267, pp. 4376- 4385 ,(1992) , 10.1016/S0021-9258(18)42846-3
T P Stauffer, H Hilfiker, E Carafoli, E E Strehler, Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. Journal of Biological Chemistry. ,vol. 268, pp. 25993- 26003 ,(1993) , 10.1016/S0021-9258(19)74484-6
A. Enyedi, A.G. Filoteo, G. Gardos, J.T. Penniston, Calmodulin-binding domains from isozymes of the plasma membrane Ca2+ pump have different regulatory properties. Journal of Biological Chemistry. ,vol. 266, pp. 8952- 8956 ,(1991) , 10.1016/S0021-9258(18)31536-9